The satisfactory food impression sense of taste, at the same time about formulation chemically-modified and when circulating it possesses sufficient hardness, and the satisfactory collapsibility inside the buccal cavity which the problem such as the being lacking and degradation does not occur inside the buccal cavity, in-mouth rapidly-disintegrable tablet which possesses sufficient hardness under opening humidity is required. As for this invention, mannitol and kishiritoru, the inorganic forma medicine, making disintegrator and karumerosu under existing of the water, drying, the collapsible grain constituent, and that collapsible grain constituent which become, blendinging the active material and the disintegrator in regard to in-mouth rapidly-disintegrable tablet which becomes, as for the said decay lock the food impression sense of taste and the hardness which are superior, collapsibility and the sufficient hardness under humidity it possesses.口腔内で良好な食感・味覚、かつ製剤化工程や流通時に欠けや粉化といった問題が生じない十分な硬度、及び口腔内での良好な崩壊性を有し、開封湿度下においても十分な硬度を有する口腔内速崩壊錠が求められている。本発明は、マンニトール、キシリトール、無機賦形剤、崩壊剤及びカルメロースを水の存在下に分散させて乾燥してなる崩壊性粒子組成物、並びにその崩壊性粒子組成物、活性物質及び崩壊剤を配合してなる口腔内速崩壊錠に関し、該崩壊錠は優れた食感・味覚、硬度、崩壊性及び湿度下における十分な硬度を有する。
