UTILISATION DES ANIMAUX TRANSGÉNIQUES FERTILES POUR LA PRODUCTION D'ANTICORPS PORTANT DES RÉGIONS VARIABLES HUMAINES

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专利权人:

Kymab Limited

发明人:

申请号：

EP15188522.5

公开号：

EP2989894A1

申请日:

2012.11.30

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates inter alia to fertile non-human vertebrates such as mice and rats useful for producing antibodies bearing human variable regions, in which endogenous antibody chain expression has been inactivated. This inactivation leads to loss of ADAM6 genes located within the rodent heavy chain locus, said genes being important for fertility. Introduction of functional copies of said ADAM6 genes is shown to allow production of fertile mice.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/