PROCEDE DE PREPARATION D'ARIPIPRAZOLE STERILE A TAILLE MOYENNE DESIREE DES PARTICULES

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专利权人:

Ltd.;Otsuka Pharmaceutical Co.

发明人:

申请号：

EP04795750.1

公开号：

EP1675593B1

申请日:

2004.10.20

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/