Margaret M. Gleeson,Soojin Kim,Donald C. Kientzler,San Kiang
申请号：
US13771691
公开号：
US20130161848A1
申请日:
2013.02.20
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.
