Leonid Beigelman,Rajendra Pandey,Vivek Kumar Rajwanshi,David Bernard Smith,Lawrence M. Blatt,Jin Hong
申请号：
US16676929
公开号：
US20200147124A1
申请日:
2019.11.07
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Various embodiments provide STOPS™； polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™； modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™； modified oligonucleotides, as determined by HBsAg Secretion Assay, is greater than that of a reference compound.
