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C4S PROTEOGLYCAN SPECIFIC TRANSPORTER MOLECULES
专利权人:
发明人:
申请号:
EP13799491.9
公开号:
EP2917227A1
申请日:
2013.11.07
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The present invention relates to isolated molecules, peptides, and polypeptides of specific consensus sequences or structures, and to compounds comprising or consisting of such molecules, peptides and polypeptides, which may act as transporter molecules that specifically recognize proteoglycans, in particular, chondroitin-4-sulfate (C4S). The isolated molecules, peptides, polypeptides and compounds of the invention may be conjugated or otherwise linked to a biologically active moiety (BAM). Thus the BAM conjugates allow the specific targeting and delivery of the BAM, which may be, for example, a peptide, chemical entity or nucleic acid, into the cytoplasm and/or nuclei of C4S expressing cells in vitro and in vivo.
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