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C6S specific transporter molecules
专利权人:
PHI PHARMA SA
发明人:
Christophe Bonny,Fabrice Chenaux,Vincent Zoete
申请号:
US15306572
公开号:
US10131690B2
申请日:
2015.04.27
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to isolated molecules, peptides, and polypeptides of specific consensus sequences or structures, and to compounds comprising or consisting of such molecules, peptides or polypeptides, that function as transporter moieties or compositions specifically recognizing the proteoglycan, chondroitin 6-sulfate (C6S). The isolated molecules, peptides, polypeptides and compounds of the invention may be conjugated or otherwise linked to a biologically active moiety (BAM). Thus the BAM conjugates allow the specific targeting and delivery of the BAM, which may be, for example, a peptide, chemical entity or nucleic acid, into the cytoplasm and/or nuclei of C6S expressing cells in vitro and in vivo.
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