The disclosure is a denoising method and an apparatus of a pulse wave signal and a pulse oximetry.The denoising method includes steps of a. normalizing a clock signal of a pulse wave obtained by transmitting lights through a living body tissue, b. using the average gradient of the normalized clock signal of the pulse wave to estimate the heart rate, and c. denoising the clock signal of the pulse wave according to the estimated heart rate.Under this circumstance, the denoising method and the apparatus of the pulse wave signal and the pulse oximetry of the present invention achieve the advantages of simple algorithm, such that the accurate measurement is implemented under low perfusion.本案係關於一種脈搏波信號的去噪處理方法和裝置及脈搏式血氧儀,該方法包括如下步驟:a.將通過對生物體組織透射光後得到的脈搏波時域信號進行歸一化;b.利用歸一化後的脈搏波時域信號的平均梯度來估算心率;c.根據所估算的心率對脈搏波時域信號進行去噪處理。本申請的脈搏波信號的去噪處理方法和裝置及脈搏式血氧儀具有算法簡單同時能在低灌注度情況下實現準確測量的優點。S01、S02、S03‧‧‧步驟