Substituted piperidine- and piperazine compounds (I), and their tautomers, salts or stereoisomers, including their mixtures in all ratios, are new. Substituted piperidine- and piperazine compounds of formula (I), and their tautomers, salts or stereoisomers, including their mixtures in all ratios, are new. R 1>； : binuclear unsaturated or aromatic heterocycle with 1-4 N-, O- and/or S atoms (unsubstituted or 1-3 times substituted by A, hal, NR 2, (CR 2) nCN, OR 5>；and/or =O)； D 1>； : C or S； G : N or C； either R 2>； : absent (when G is N) or H or Ar 2>；(when G is C)； or CR 2>；+R 2>；, (E-W 1>；)R 2>；+R 2>； : spirocyclic ring of 3H-isobenzofuran-1-one-3,3-diyl, chroman-3-one-2,2-diyl, substituted oxazolidin-2-one moiety of formula (a) or imidazolidine-2,4-dione-5,5-diyl； Q : optionally branched 1-4C alkylene, where 1-5 H atoms are substituted by A, (CR 2) n[X(CR 2) n] p-Y 1>；, F and/or Cl； R 3>； : H, A, Ar 1>；, OR, SR, NR 2, hal, NO 2, CN or (CR 2) n[X(CR 2) n] p-Y 1>；； X : O, NR or CR 2； Y 1>； : OR or NR 2； R 5>； : H or optionally branched 1-6C alkyl, where 1-7 H atoms are substituted by F and/or Cl； E : COO(CR 2) n, COO(CRR 4>；), CO(CR 2) mO, CONH(CR 2) n, C(=S)NH(CR 2) n, S(O) qNH(CR 2) n, S(O) q(CR 2) n, CO(CR 2) n, (CR 2) n, CO(CR 2) mO(CR 2) n, CO(CR 2) mNH(CR 2) n, CO(CH 2) nCO, COCHR 6>；CHR 7>；, C(=S)O(CR 2) n, CO(CRR 4>；)(CR 2) n, COO(CRR 4>；), (CRR 4>；)(CR 2) n, S(O) qCR=CR, COCR=CR, (CR 2) mCO, CONH(CR 2) mCRR 4>；or (CR 2) mCONR； R 4>； : COOR 5>；, Ar 2>；, (CR 2) nNR 2, OH, NRCOOR 8>；or NRCOOA； R 6>；R 7>； : (CH 2) 1 - 4； R 8>； : phenyl, naphthyl or fluorenyl； R : H or optionally branched 1-6C alkyl； W 1>； : Ar 1>；or Het； Ar 1>； : phenyl, indanyl, naphthyl or biphenyl (unsubstituted or 1-3 times substituted by hal, A, (CR 2) nOR, O(CR 2) n, Ar 2>；, (CR 2) nNR 2, SR, NO 2, CN, COOR, CONR 2, NRCOA, NRSO 2A, SO 2NR 2, S(O) qA, CO-Het, (CR 2) nHet, O(CR 2) nNR 2, O(CR 2) nHet, NHCOOA, NHCONR 2, NHCO
