The present invention relates to a composition for the prevention and treatment of obesity containing a combination extract consisting of lacquer tree and chinensis as an active ingredient. Targeting the combination extract according to the present invention, it was confirmed that weight gain was excellently suppressed through an experiment to verify the efficacy of improving obesity in an obesity model due to a fat diet for the combination extract of the present invention (Experimental Example 1), and measurement of serum lipid content In the experiment, it was confirmed that the accumulation of intracellular fat and the accumulation of triglycerides and cholesterol were strongly inhibited (Experimental Example 2): In the experiment of hepatocyte tissue staining through Oil Red staining, the accumulation of intracellular fat and the accumulation of triglycerides and cholesterol It was confirmed that it strongly inhibits (Experimental Example 3)； Through immuno-blotting assay, the expression of endoplasmic reticulum stress-related proteins is reduced, the expression of SREBP-1 and FAS is suppressed, the phosphorylation of mTORC1, P70S6K, and 4EBP-1 is reduced, and the phosphorylation of AMPK is increased. It was confirmed to increase (Experimental Example 4)； By confirming that the activity of GSH, GPx, SOD and CAT increases in a concentration-dependent manner, it was confirmed that oxidative damage to the liver by a high fat diet was protected by inhibiting lipid peroxide substances and maintaining the detoxification function of toxic substances in the body (Experimental Example 5). By doing so, the combination extract composed of poison ivy and chinensis of the present invention can be usefully used in the prevention or treatment of obesity.본 발명은 옻나무 및 두충으로 구성된 조합 추출물을 유효성분으로 함유하는 비만증의 예방 및 치료용 조성물에 관한 것이다. 본 발명에 따른 조합 추출물을 대상으로 본 발명의 조합 추출물을 대상으로 지방식이로 인한 비만모델에서 비만개선 효능 검증실험을 통하여 체중 증가를 탁월하게 억제됨을 확인하였으며(실험예 1), 혈청 지질 함량 측정실험에서 세포 내 지방의 축적 및 중성지방과 콜레스테롤의 축적을 강력하게
