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4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES FOR TREATING CHRONIC WOUNDS
专利权人:
发明人:
申请号:
EP16793879.4
公开号:
EP3373936A1
申请日:
2016.11.09
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The invention relates to 4-(4-Cyano-2-thioaryl)dihydropyrimidinones of the formula (I) known from WO 2009/080199(A1) for use in a method for the treatment and/or recurrence rate reduction of a chronic wound selected from different types of ulcers and a chronic wound associated with Behçets disease wherein the compound of the formula (I) is administered orally and wherein the treatment and/or reduction of recurrence rate of the chronic wound causes one or more of the effects selected from an increased wound closure rate, a reduced wound size, a shorter time to wound closure, an increase of the reepithelialisation of the chronic wound, an increase of the deposition of extracellular matrix such as collagen in the chronic wound, and a reduction of pain related to the chronic wound. The invention further relates to compounds of the formula (I) for use in a method for the treatment of neutrophilic dermatoses or for use in a method for the treatment of autoimmune blistering dermatoses.
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中国工程科技知识中心
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