The United States Government, as Represented by the Secretary of the Department of Health and Huma;The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人:
Edward E. MITRE,Christopher MORRIS,Sasisekhar BENNURU,Thomas NUTMAN
申请号：
US15558336
公开号：
US20180064791A1
申请日:
2016.03.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure is directed to an immunogenic composition including: at least one or at least two isolated polypeptides or immunogenic fragments thereof, and optionally a pharmaceutically acceptable carrier, wherein each polypeptide is expressed on a luminal surface of an intestine of a filarial worm, wherein each polypeptide is expressed at a level at least two-fold higher in the intestine in comparison to the level of expression of each polypeptide in a reproductive tract or a body wall of the filarial worm, wherein each isolated polypeptide has at least one transmembrane domain, and wherein each polypeptide is a non-mitochondrial polypeptide. Also provided herein is a method for preventing or treating a filarial disease.
