THE UNITED STATES GOVERNMENT, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES; INC.;THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.;THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE
发明人:
MITRE, EDWARD E.,MORRIS, CHRISTOPHER,BENNURU, SASISEKHAR,NUTMAN, THOMAS
申请号：
CA2979840
公开号：
CA2979840A1
申请日:
2016.03.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present disclosure is directed to an immunogenic composition and method for preventing or treating a filarial disease including: at least one or at least two isolated polypeptides or immunogenic fragments thereof, and optionally a pharmaceutically acceptable carrier, wherein each polypeptide is expressed on a luminal surface of an intestine of a filarial worm, wherein each polypeptide is expressed at a level at least two-fold higher in the intestine in comparison to the level of expression of each polypeptide in a reproductive tract or a body wall of the filarial worm, wherein each isolated polypeptide has at least one transmembrane domain, and wherein each polypeptide is a non-mitochondrial polypeptide.
