The present invention relates to a porcine parvovirus and porcine reproductive and respiratory syndrome virus vaccine for protecting a subject, preferably swine, against diseases associated with porcine parvovirus and porcine reproductive and respiratory syndrome virus. The present invention further relates to methods of producing immunogenic compositions as well as such immunogenic compositions exhibiting reduced virucidal activity.本發明係關於一種豬小病毒及豬生殖與呼吸道症候群病毒疫苗,其用於保護個體、較佳地豬,以抵抗與豬小病毒及豬生殖與呼吸道症候群病毒有關之疾病。本發明另外關於製造展現減小殺病毒活性之免疫原性組合物之方法以及該等免疫原性組合物。