The invention provides a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of a gene selected from Bscl2, Srxnl, Cbr3, Ephxl, Nope, Cdknla, Perp, Pltp, Cgrefl, Ltb4r1, Btg2, Gpx2, Ltb4r2, Ddit4l, Fosl1, and Egr1, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent. The invention also provides a method of detecting a genotoxic or oxidative stress- inducing agent comprising subjecting a cell containing the polynucleotide of the invention to a test agent and assessing the expression of the reporter sequence. The invention provides a method of detecting a genotoxic or oxidative stress-inducing agent comprising subjecting one or more cells that comprise a reporter sequence operatively linked to a regulatory element of a gene, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent, to a test agent, and assessing the expression of the one or more reporter sequences wherein at least one cell subjected to a test agent comprises a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of the Bscl2 gene.La présente invention concerne un polynucléotide comprenant une séquence rapporteur liée de manière fonctionnelle à un élément régulateur dun gène choisi parmi Bscl2, Srxnl, Cbr3, Ephxl, Nope, Cdknla, Perp, Pltp, Cgrefl, Ltb4r1, Btg2, Gpx2, Ltb4r2, Ddit4l, Fosl1 et Egr1, ledit élément régulateur stimulant lexpression de la séquence rapporteur en réponse à un agent génotoxique ou à un agent provoquant un stress oxydatif. Linvention a également pour objet un procédé de détection dun agent génotoxique ou dun agent provoquant un stress oxydatif comprenant la soumission dune cellule contenant le polynucléotide de linvention à un agent à tester et lestimation de lexpression de la séquence rapporteur. Linvention a pour objet un pr
