Disclose the skin preparations for extenal use containing the wax fine dispersion constituent containing oil-soluble medicament, solid is contained to semisolid wax, non-ionic surfactant, water system dispersion solvent and oil-soluble medicament in the aforementioned wax fine dispersion constituent system containing oil-soluble medicament, non-ionic surfactant/wax mass ratio is 1.0 or more, packet oil-soluble medicament in wax system, with solid to semi-solid, the above-mentioned skin preparations for extenal use of institute's winner in fine dispersion what water system dispersion solvent.According to the present invention, it is sustained by the initial stage seepage velocity of control oil-soluble medicament (view alcohol, fertility alcohol acetate etc.), lowers skin irritatin, there is the tender sense of touch of water, safety is excellent, and stability also excellent skin preparations for extenal use.揭示含含有油溶性藥劑之蠟微細分散組成物之皮膚外用劑，前述含有油溶性藥劑之蠟微細分散組成物係含有固體至半固體的蠟、非離子界面活性劑、水系分散溶劑、及油溶性藥劑，非離子界面活性劑/蠟之質量比為1.0以上，蠟係內包油溶性藥劑，以固體至半固體狀，微細分散於水系分散溶劑中所成者之上述皮膚外用劑。依據本發明，藉由控制油溶性藥劑(視網醇、生育醇醋酸酯等)之初期滲透速度而緩釋，減低皮膚刺激，有水嫩觸感，安全性優異，而且安定性亦優異之皮膚外用劑。
