The present invention relates to the microstructured bodies and preparation method thereof comprising biocompatibility macromolecule or binder.The present inventor ensures best tip (tip) angle and diameter range for Cutaneous permeation by the form optimization aspect ratio of microstructured bodies.In particular, the B types of the present invention and the microstructured bodies of C types can be by making the osmotic resistance caused by skin elasticity when skin attachment minimize, to improve the permeability (60% or more) of structure and the skin internal absorption factor of active ingredient.Also, the microstructured bodies of the D types of the present invention make Cutaneous permeation be easy by being applicable in triplen by the mechanical strength maximization of structure.In the present invention, the advantages of in the case where being applicable in hexagon (Hexagonal) arrangement mode to multiple microstructured bodies, having when skin attachment, uniform pressure can be transmitted to entire microstructured bodies.
