Triazolothienopyrimidine compound inhibitors of urea transporters and methods of using inhibitors

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专利权人:

The Regents of the University of California

发明人:

Marc Anderson,Alan S. Verkman

申请号：

US14388645

公开号：

US09303042B2

申请日:

2013.03.27

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.

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中国工程科技知识中心

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