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POSTUPAK PROIZVODNJE PRASUGREL HIDROKLORIDA VISOKE ČISTOĆE
专利权人:
DAIICHI SANKYO COMPANY, LIMITED;UBE INDUSTRIES, LTD.
发明人:
MIYATA, HIROYUKI,WADA, YUKINORI,YOKOTA, NAOYUKI
申请号:
HRP20140668
公开号:
HRP20140668T1
申请日:
2014.07.14
申请国别(地区):
HR
年份:
2014
代理人:
摘要:
An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like. In the formulae, R represents a protecting group for a hydroxyl group. A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.
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