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Process for production of prasugrel hydrochloride having high purity
专利权人:
UBE INDUSTRIES, LTD.; LTD.;UBE INDUSTRIES;DAIICHI SANKYO COMPANY, LIMITED
发明人:
YOKOTA, NAOYUKI,WADA, YUKINORI,MIYATA, HIROYUKI
申请号:
AU2008222000
公开号:
AU2008222000B2
申请日:
2008.02.29
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The object is to provide prasugrel hydrochloride or the like having a reduced CATP content. Specifically disclosed is a process for producing prasugrel hydrochloride shown by the scheme below, wherein the temperature at which a chlorinating agent is added dropwisely or added in step (i) and the reaction temperature after the dropwise addition or addition of the chlorinating agent are adjusted to lower temperatures. Step i Step ii Step iii Step iv wherein R represents a protective group for a hydroxy group.
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