The present disclosure provides a compression hosiery designed to be worn on a human leg. The compression hosiery includes a first portion adapted for a lower portion of a human leg and having a first pressure gradient slope and a second portion adapted for an upper portion of a human leg and having a second pressure gradient slope. The pressure gradient slopes generally decrease in a direction from the first portion to the second portion such that the compressive forces at the first portion are greater than the compressive forces at the second portion when the hosiery is worn.