The present disclosure concerns effervescent compositions and methods ofmaking and using thesame. In some embodiments, the disclosed effervescent compositions are formedfrom an inputblend comprising an acid and a base by granulating the input blend in a twin-screw processor.The granules formed from the input blend can be formed by an in situgranulating agent, whichcan be a portion of the acid that melts during granulation. In someembodiments, theeffervescent compositions can be made using a twin-screw processor comprisingan intake zonefor receiving an input blend comprising an acid and a base; a granulationinitiation zone formelting only a portion of the acid to serve as an in situ granulating agent; agranulationcompletion zone for granulating the input blend; and an outlet for dischargingthe granules.