MADGE, DAVID,CHAN, FIONA,JOHN, DEREK EDWARD,EDWARDS, SIMON D.,BLUNT, RICHARD,HARTZOULAKIS, BASIL,BROWN, LINDSAY
申请号：
CA2855346
公开号：
CA2855346A1
申请日:
2012.11.15
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides compounds of formula (I): (Formula (I)； wherein A, R1, R2, R3 I, V, X, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.
