BRASIL HARTZOULAKIS,DAVID MADGE,DEREK EDWARD JOHN,FIONA CHAN,LINDSAY BROWN,RICHARD BLUNT,SIMON D. EDWARDS
申请号：
BR112014011671
公开号：
BR112014011671A2
申请日:
2012.11.15
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention provides compounds of formula (I): (Formula (I)； wherein A, R1, R2, R3I, V, X, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.
