Guiding catheter support devices, systems, and methods for stabilizing a guiding catheter while positioned in a vessel of a patient are disclosed. The device comprises a stabilizing wire with an elongate portion and a fortified end, wherein the fortified end is more rigid than the elongate portion. The stabilizing wire is inserted into a guiding catheter while it is positioned in a vessel of a patient and increases the rigidity of at least a portion of the guiding catheter thereby providing support and stabilizing the catheter. A standard guiding catheter may be used or a guiding catheter with a primary lumen and a stabilization lumen having a blind distal end may be used, wherein the stabilizing wire is inserted into the stabilization lumen.