Darell D. Bigner,Matthias Gromeier,Smita Nair,Vidyalakshmi Chandramohan
申请号:
US15768147
公开号:
US20180296614A1
申请日:
2016.10.14
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. Combination with immune checkpoint inhibitors increases the anti-tumor effect. Tumors of different types are susceptible to the combination treatment, including but not limited to melanoma, glioglastoma, renal cell carcinoma, prostate cancer, breast cancer, lung cancer, medulloblastoma, and colorectal cancer.