Kumar, Sanjeev,Waldo, Jesse,Jaipuri, Firoz,Mautino, Mario
申请号:
AU2014241079
公开号:
AU2014241079B2
申请日:
2014.03.10
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.