Michael E. Hogan,Stephen Hughes,Antonella Conforti,Luigi Aurisicchio,Fabio Palombo
申请号：
US16703915
公开号：
US20200224206A1
申请日:
2019.12.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are non-plasmid derived DNA vaccines comprised solely of enzymatically produced amplicon expression vectors and their method of use to elicit antigen-specific immune responses in a subject. The enzymatically produced amplicon expression vectors may be specifically utilized as a DNA based cancer vaccine to express desired antigens or other immunogenic polypeptides within a subject to induce a specific anti-cancer antigen-specific immune response. The enzymatically produced amplicon expression vectors may also be utilized to express cancer-specific neoantigens.
