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Adipocyte-specific constructs and methods for inhibiting platelet-type 12 lipoxygenase expression
专利权人:
Gary Weisinger
发明人:
Gary Weisinger,Rona Limor,Naftali Stern
申请号:
US12513006
公开号:
US09279127B2
申请日:
2007.11.01
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention is directed to constructs, compositions and methods for modulating platelet-type 12 lipoxygenase (12-LO) in adipose tissue in vivo. Specifically, the invention provides constructs encoding expression-inhibiting oligonucleic acids, e.g., antisense and RNA interfering (RNAi) molecules, targeted to a platelet-type 12-LO gene or a transcript thereof, which are capable of reducing or silencing platelet-type 12-LO expression specifically in adipocytes and pre-adipocytes. Vectors of these constructs (including, but not limited to, viral vectors), compositions of them and methods of using same for the treatment and amelioration of conditions associated with excess fat cell mass and obesity are also provided.
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