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COMPOSITIONS AND METHODS FOR SILENCING EBOLA VIRUS GENE EXPRESSION
专利权人:
发明人:
THOMAS W. GEISBERT,Amy C.H. Lee,Marjorie Robbins,Vandana Sood,Adam Judge,Lisa E. Hensley,Ian MacLachlan
申请号:
US14880082
公开号:
US20160264971A1
申请日:
2015.10.09
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene expression and methods of using such compositions to silence EBOV gene expression. More particularly, the invention provides unmodified and chemically modified interfering RNA which silence EBOV gene expression and methods of use thereof, e.g., for preventing or treating EBOV infections caused by one or more EBOV species such as Zaire EBOV. The invention also provides serum-stable nucleic acid-lipid particles comprising one or more interfering RNA molecules, a cationic lipid, and a non-cationic lipid, which can further comprise a conjugated lipid that inhibits aggregation of particles. Methods of silencing EBOV gene expression by administering one or more interfering RNA molecules to a mammalian subject are also provided.
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