VAN VLASSELAER, PETER,PARRY, GRAHAM,STAGLIANO, NANCY E.,PANICKER, SANDIP
申请号：
CA3055781
公开号：
CA3055781A1
申请日:
2018.03.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present disclosure provides methods of treating a complement-mediated disease or disorder in an individual, and methods of inhibiting activation of complement component C4 in an individual in need thereof. The methods comprise administering to the individual an anti-C1s antibody. The methods also comprise administering an anti-C1s antibody in a fixed dose, e.g., 5.5 g, 6.5 g, or 7.5 g. The methods also comprise administering an effective dose of an anti-C1s antibody to the individual to achieve a minimum serum level of anti-C1s antibody for therapeutic effect.
