The United States of America as represented by the Secretary of the Department of Health and Human Services; Centers for Disease Control and Prevention
发明人:
Todd G. Smith,Xianfu Wu
申请号：
US14813427
公开号：
US09809643B2
申请日:
2015.07.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.
