INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DONG QI,ROGER INNES,SANG HEE KIM
申请号：
BR112015005389
公开号：
BR112015005389A2
申请日:
2013.09.04
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract compositions, systems and methods are provided for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins within plant cells. briefly, the compositions, systems, and methods are based upon plant substrate proteins that are targeted by pathogen-specific proteases and that activate nucleotide binding site-leucine rich repeat (nb-lrr) disease resistance proteins when cleaved by the protease. these substrate proteins are modified such that the endogenous protease recognition sequence is replaced by a protease recognition sequence specific to a different pathogen protease (i.e., a heterologous protease recognition sequence). the modified plant substrate protein therefore can be used in connection with its corresponding nb-lrr protein to activate resistance in response to cleavage by the heterologous pathogen-specific protease. when activated by the plant pathogen-specific protease, the pair initiates host defense responses thereto, including programmed cell death. __________________________ translation of the abstract patent summary of the invention: "compositions and systems for conferring disease resistance on plants and methods of using them". These are compositions, systems and methods for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins within plant cells. In short, the compositions, systems and methods are based on plant substrate proteins that are targeted by pathogen-specific proteases and which activate nucleotide binding site leucine-rich repeat resistance (nb-1rr) proteins. ) when cleaved by the protease. such substrate proteins are modified such that the endogenous protease recognition sequence is replaced by a protease recognition sequence specific for a different pathogen protease (i.e. a heterologous protease recognition sequence). ). therefore, the modified plant substrate protein may be used in conjunction with its corresponding nb-1rr protein t
