Chymase mediated diseases, for example, in the prevention and / or treatment of eye diseases such as skin diseases, circulatory system diseases, digestive system disorders, respiratory disease, or liver disease, has a very strong chymase inhibitory activity, it is possible to provide a drug as an active ingredient a compound metabolic stability and a high, high level of safety. The general formula (I) [Formula 1] (Wherein,. Same meanings as symbols described in the specification all symbols) compound represented by a salt thereof, a prodrug thereof, or a solvate thereof, the N- or oxide thereof, a chymase mediated sexual disorders, eg, in the prevention and / or treatment of eye diseases such as skin diseases, cardiovascular diseases, digestive system diseases, respiratory diseases, or liver disease, and is useful as a drug component having a chymase inhibitory activity.キマーゼ介在性疾患、例えば、皮膚疾患、循環器系疾患、消化器系疾患、呼吸器系疾患、肝疾患、または眼疾患等の予防および/または治療において、極めて強力なキマーゼ阻害活性を有し、安全性の高い、かつ代謝安定性が高い化合物を有効成分とする薬剤を提供すること。一般式(I)【化1】(式中、すべての記号は、明細書記載の記号と同じ意味を表す。)で示される化合物、その塩、そのN-オキシド体もしくはそれらの溶媒和物、またはそれらのプロドラッグは、キマーゼ介在性疾患、例えば、皮膚疾患、循環器系疾患、消化器系疾患、呼吸器系疾患、肝疾患、または眼疾患等の予防および/または治療において、キマーゼ阻害活性を有する薬剤成分として有用である。
