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Pyrimidine derivatives for the treatment of bacterial diseases
专利权人:
Janssen Sciences Ireland UC
发明人:
BONFANTI, Jean-François,MULLER, Philippe,DOUBLET, Frédéric,FORTIN, Jérôme,LOUNIS, Nacer
申请号:
ES13722329
公开号:
ES2676189T3
申请日:
2013.04.30
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of formula I for use as a medicament, where the use is in the treatment of a bacterial infection, where formula I represents: ** Formula ** where: Y represents: ** Formula ** (ii ) -CF3; (iii) -N (C1-6 alkyl) 2; or (iv) C3-6 cycloalkyl; Nv, Nw, Nx, Ny and Nz independently represent -N>; = or -C (H)>; = but where only a maximum of three of Nv, Nw, Nx, Ny and Nz can represent -N>; =; n represents 0, 1 or 2; X1 and X2 independently represent -N- or -C (H) -; when X1 represents -N-, Q1 represents a direct link, -C (O) - or -S (O) 2-; when X1 represents -C (H) -, Q1 represents a direct link or -N (Rz) -; Rz represents hydrogen or C1-6 alkyl; Rx represents C1-6 alkyl (optionally substituted by one or more substituents that are selected from>; = O and A1), aryl or heteroaryl (the latter two groups being each optionally substituted by one or more substituents that are selected from A2 and A3 , respectively); Ry, Ry1 and Ry2 independently represent hydrogen, halo, -CN, -OR10, -N (R11) (R12) or C1-6 alkyl (optionally substituted by one or more halo atoms); A1, A2, A3 and A4 independently represent halo, -CN, -OR1, -S (O) 0-2 C1-3alkyl, C1-6alkyl (optionally substituted by one or more halo substituents), heterocycloalkyl (optionally substituted by one or more substituents that are selected from C1-3alkyl and halo), aryl or heteroaryl (the latter two groups being optionally substituted by one or more substituents that are selected from B1 and B2, respectively); each R1 and R10 independently represent hydrogen, C1-6 alkyl (optionally substituted by one or more halo substituents), aryl or heteroaryl (the latter two groups being optionally substituted by one or more substituents that are selected from halo, C1-3 alkyl and -O-C1-3 alkyl); R11 and R12 independently represent hydrogen or C1-6 alkyl; B1 and B2 independently represent halo, - CN, C1-6 alkyl (optionally substituted by one or more halo atoms), -OH or -O-C1-6 alkyl (optionally substituted by one or more
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