Present invention relates in general to the combined acology of supermolecule, including composition that is identical, and its using. Particularly, the disclosure provides creation supramolecular assembly, such as hydrophobic taxane-lipoid covalent conjugates within lipid bilayer, and providing leads to increased intratumoral concentrations, therefore extra stabilization the effect of increase. The disclosure also provides the combined acology of supermolecule, wherein one taxane-lipid conjugate and be each optionally the one or more platinum compounds for being conjugated with a lipoid, a kinase inhibitor and an immunomodulator are combined.
