PROBLEM TO BE SOLVED: To provide a new human hemopoietin receptor protein and DNA encoding the same.SOLUTION: There is disclosed a new hemopoietin receptor gene (NR10) having a specific base sequence isolated on the basis of a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. NR10 is a new hemopoietin receptor molecule implicated in the regulation of the immune system and hematopoiesis in vivo and useful in screening for new hematopoietic factors capable of functionally binding to the receptor, or developing medicines to treat diseases related with the immune system or hematopoietic system.COPYRIGHT: (C)2012,JPO&INPIT【課題】新規ヒトヘモポエチン受容体蛋白質と、それをコードするDNAの提供。【解決手段】既知のヘモポエチン受容体のアミノ酸配列から保存されているモチーフを抽出し、予測した配列をもとに単離した特定の塩基配列を有する新規なヘモポエチン受容体遺伝子(NR10)。NR10は生体免疫調節、造血細胞調節に関与する新規なヘモポエチン受容体分子であり、同受容体と機能結合し得る新規造血性因子の検索や、免疫・造血系関連疾患の治療薬の開発に有用である。【選択図】図2
