PROBLEM TO BE SOLVED: To provide methods of exterminating harmful bion groups, such as invasive introduced species, with low cost, in which the increased number of the total population is suppressed and the risk of rebound is suppressed.SOLUTION: The size of a feral population is reduced by releasing male or supermale individuals that multiply hold female specific sterilization genes into a feral population, mating female individuals in the feral population to the male individuals, and generating progeny individuals that hold female specific sterilization genes in a feral population.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】低コストで、総個体数の上昇が抑制され、リバウンドのリスクが抑制された、侵略的外来種等の有害な生物個体群を根絶する方法を提供すること。【解決手段】雌特異的不妊化遺伝子を多重に保持する雄または超雄個体を、野生個体群中に放出し、当該雄個体と当該野生個体群中の雌個体とを交配させ、野生個体群中に、雌特異的不妊化遺伝子を保持する子孫個体を生じさせることにより、当該野生個体群サイズを縮小する。【選択図】なし