Compositions and methods are provided for treating joint conditions, such asosteoarthritis and/or the pain associated therewith. The compositions andmethodsutilize a first component, namely hyaluraonic acid ("HA"), in combination withalyophilized second component that is effective to at least temporarily reducetheviscosity of the HA. In an exemplary embodiment, the second component is oneormore glycosaminoglycans ("GAG"), such as chondroitin sulfate ("CS"), includingCS4and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate.Thecomposition can optionally include other joint supplements, such asglucosamine("GlcN")
