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Eliglustat (Genz 112638) jako inhibitor syntazy glukozyloceramidowej do zastosowania w sposobie leczenia choroby Fabry’ego lub choroby Gauchera, przy czym sposób obejmuje dostosowanie indywidualnej dawki terapeutycznej do metabolizmu P450 u pacjenta
专利权人:
Genzyme Corporation
发明人:
LIU, HANLAN,WILLIS, CHRIS,BHARDWAJ, RENU,COPELAND, DIANE P.,HARIANAWALA, ABIZER,SKELL, JEFFREY,MARSHALL, JOHN,KOCHLING, JIANMEI,PALACE, GERARD,PETERSCHMITT, JUDITH,SIEGEL, CRAIG,CHENG, SENG
申请号:
PL16175117
公开号:
PL3133070T3
申请日:
2010.11.24
申请国别(地区):
PL
年份:
2020
代理人:
摘要:
The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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