The present invention provides1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.本發明提供了作為PDE1抑制劑的具有化學式(I)之1H-吡唑并[4,3-b]吡啶-7-胺及其作為藥劑之用途,特別是用於治療神經退行性障礙和精神障礙。