The present invention provides halogenated quinazolin-THF-amines as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.本發明提供了作為PDE1抑制劑之鹵化喹唑啉-THF-胺及其作為藥劑之用途,特別是用於治療神經退行性障礙和精神障礙。