Sinclair, David A.,Zipkin, Robert E.,Bitterman, Kevin J.,Howitz, Konrad T.,Lamming, Dudley W.
申请号：
AU2013201279
公开号：
AU2013201279A1
申请日:
2013.03.05
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013201279A120130321.pdf#####Abstract Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members p53 activity apoptosis lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an 5 activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
