President and Fellows of Harvard College;Biomol International L.P.
发明人:
Sinclair, David A.,Zipkin, Robert E.,Bitterman, Kevin J.,Howitz, Konrad T.,Lamming, Dudley W.
申请号：
AU2011201238
公开号：
AU2011201238B2
申请日:
2011.03.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011201238B220121206.pdf#####Abstract Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members； p53 activity； apoptosis； lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an 5 activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin； or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
