Jackson, David Y.,Gazzard, Lewis J.,Um, Joann,Ha, Edward HyungSuk
申请号：
AU2006320945
公开号：
AU2006320945B8
申请日:
2006.01.30
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention relates to bis 1, 8 naphthalimide compounds including antibodydrag conjugate (ADC) compounds represented by Formula (I) : where one or more1, 8 bis-naphthalimide drug moieties (D) having Formulas (IIa) and (IIb) arecovalently linked, through the wavy line, by a linker (L) to an antibody (Ab).The invention also relates to heterocyclic-substituted 1, 8 bis-naphthalimidecompounds having Formula (XV). The invention also relates to pharmaceuticalcompositions comprising an effective amount of a Formula (I) ADC or Formula (XV)heterocyclic-substituted 1, 8 bis-naphthalimide compound for treatment ofhyperproliferative disorders and other disorders. The invention also relatesto methods for killing or inhibiting the proliferation of tumor cells or cancercells including administering to a patient an effective amount of a Formula (I)ADC or Formula (XV) compound.
