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ניקוי של קונג'וגת של נוגדן תרופה (adc)
专利权人:
ABBVIE INC.
发明人:
申请号:
IL24100415
公开号:
IL241004D0
申请日:
2015.09.01
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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