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COMPOSITION AND METHOD FOR TREATMENT OF DISEASES ASSOCIATED WITH CENTRAL NERVOUS SYSTEM INFLAMMATION
专利权人:
AMRITA VISHWA VIDYAPEETHAM
发明人:
GOPI C. MOHAN,KRISHNAKUMAR N. MENON,JANE JOSE
申请号:
US16363977
公开号:
US20190298695A1
申请日:
2019.03.25
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The invention discloses compositions, methods and kits for use in treatment of diseases associated with CNS inflammation such as multiple sclerosis. The composition includes therapeutically effective amount of (1-H indazole-4yl-)methanol. Further, a method of inhibiting glial maturation factor beta (GMF-β) phosphorylation activity in cells is disclosed. The method of treating subjects includes administering a therapeutic effective amount of the composition. The administered composition suppresses the activity of the overexpressed GMF-β either by binding or blocking its phosphorylating sites and ameliorating the inflammatory condition. The disclosed compositions, methods and kits may be used in the treatment of diseases like multiple sclerosis, Alzheimer's disease, Parkinson's disease or cancer.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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