Abhijit S. Bapat;Sayali S. Shah;Malika Mishra;Gauthami Mahesh;D. Sreedhar Reddy;Sumana Ghosh;Nidhi Arora;Rajesh S. Gokhale;Suresh R. Chawrai;Shiladitya Sengupta;Sudhanand Prasad;Kirti Bajaj
发明人:
Abhijit S. Bapat,Gauthami Mahesh,Rajesh S. Gokhale,Sayali S. Shah,Shiladitya Sengupta,Sudhanand Prasad,Sumana Ghosh,Suresh R. Chawrai,Nidhi Arora,D. Sreedhar Reddy,Malika Mishra,Kirti Bajaj
申请号：
US14128281
公开号：
US20140364595A1
申请日:
2012.06.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n； (ii) [(AFA)m′-X]p-L； (iii) AFA-[X-(L)n′]q； or (iv) (AFA)m″-X, wherein: AFA is an antifungal agent or an antibacterial agent； L is a carrier； X is a linker； m ranges from 1 to 10； n ranges from 2 to 10； m′ is 1 to 10； p is 1 to 10； n′ is 1 to 10； and q is 1 to 10, provided that q′ and n are not both 1； and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.
