Lu, Yunfeng,Yan, Ming,Chen, Irvin S. Y.,Liang, Min
申请号：
AU2013358922
公开号：
AU2013358922B2
申请日:
2013.12.16
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The invention provides novel methods, materials and systems that can be used to generate viral vectors having altered tissue and cell targeting abilities. In illustrative embodiments of the invention, the specificity of lentiviral vectors was modulated by a thin polymer shell that synthesized and coupled to the viral envelope in situ. The polymer shell can confers such vectors with new targeting ability via agents such as cyclic RGD (cRGD) peptides that are coupled to the polymer shell. These polymer encapsulated viral vectors exhibit a number of highly desirable characteristics including a higher thermal stability, resistance to serum inactivation
