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Chimeric FVII-XTEN molecules and uses thereof
专利权人:
BIOGEN IDEC MA INC.
发明人:
SALAS, JOE,TAN, SIYUAN,PETERS, ROBERT
申请号:
TW103118805
公开号:
TW201536811A
申请日:
2014.05.29
申请国别(地区):
TW
年份:
2015
代理人:
摘要:
The present invention provides chimeric FVII molecules comprising FVII, an XTEN polypeptide, and an antibody and antigen-binding molecules thereof which specifically bind the [alpha] and/or [beta] subunits of the non-active form of the GPIIb/IIIIa receptor. The antibodies and antigen-binding molecules can be genetically fused and/or conjugated to heterologous moieties, e.g., half-life extending moiety. The invention also includes methods of producing and using the chimeric molecules.
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中国工程科技知识中心
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